In this issue of \u003ci\u003eClinics in Plastic Surgery\u003c/i\u003e, guest editors Drs. Kevin C. Chung and Brian Starr bring their considerable expertise to the topic of \u003cb\u003eHand and Upper Extremity Surgery\u003c/b\u003e. Top experts in the field discuss key topics such as principles for achieving predictable outcomes in flexor tendon repair; nerve vs. tendon transfers in the management of isolated upper extremity peripheral nerve injuries; free functional muscle transfer; current and future directions for upper extremity amputations: TMR vs. RPNI; and more.\u003cul\u003e\u003cli\u003eContains \u003cb\u003e13 relevant, practice-oriented topics\u003c/b\u003e including optimizing outcomes in revision peripheral nerve surgery; the mangled upper extremity: algorithm for salvage/my workhorse flaps; bone grafts and flaps in the management of complex upper extremity defects; optimizing outcomes in the management of the burned hand; preserving and reconstructing the traumatized thumb; and more.\u003c/li\u003e\u003cli\u003eProvides in-depth \u003cb\u003eclinical reviews on hand and upper extremity surgery\u003c/b\u003e, offering actionable insights for clinical practice.\u003c/li\u003e\u003cli\u003ePresents the \u003cb\u003elatest information on this timely, focused topic\u003c/b\u003e under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.\u003c/li\u003e\u003c/ul\u003e